Here is a way to increase preformance in the game:

1. Open up notepad and start a new file.

2. Type in the following: start /low vampire.exe -console -heapsize XXXXXX

Where XXXXXX is half your RAM in KB. For instance, if your CPU has 1 GB of 
RAM you would replace XXXXXX with 500000. If is has 512 MB of RAM, you'd 
replace XXXXXX with 250000.

3. Save the file as Vampire.txt

4. Place it into your main Vampire Bloodlines directory, the default is: 
   C:\Program Files\Activision\Vampire - Bloodlines

5. Rename it to Vampire.bat

6. Go to you desktop and Right-Click on the shortcut to Bloodlines. 
   Choose the "Properties" option.

7. In the target box, you should see something like this:
   "C:\Program Files\Activision\Vampire - Bloodlines\Vampire.exe"

8. Change Vampire.exe to Vampire.bat

And your done.

If you ever want to add anything more to your shortcut command line, 
just rename the .bat back to .txt and edit it to add whatever you 
want. Just remember to change it back into a .bat file when your done.