When you do a spelling check, if the spelling checker finds a word that isn't in the Microsoft PowerPoint dictionary, it stops on the word and displays the Spelling dialog box. At that point, you can add the word in question to a custom dictionary.
Tip
If you have automatic spelling checks turned on, words that aren't in the PowerPoint dictionary will have a wavy, red underline. Right-click the word that you want to add, and then click Add on the shortcut menu.