Document 0001
 DOCN  M9610001
 TI    Progressive joint destruction in a human immunodeficiency virus-infected
       patient with rheumatoid arthritis.
 DT    9601
 AU    Muller-Ladner U; Kriegsmann J; Gay RE; Koopman WJ; Gay S; Chatham WW;
       University of Alabama at Birmingham 35294-0006, USA.
 SO    Arthritis Rheum. 1995 Sep;38(9):1328-32. Unique Identifier : AIDSLINE
       MED/96016065
 AB    This article reports the case of a 63-year-old patient with rheumatoid
       arthritis (RA) whose symptoms of RA improved after the occurrence of a
       secondary human immunodeficiency virus (HIV) infection; however, the HIV
       infection did not affect the histologic parameters of joint destruction
       to the same extent as it did the clinical symptoms. Histologic and
       immunohistologic joint examinations of this patient revealed an ongoing
       production of cartilage- and bone-degrading enzymes by macrophages and
       fibroblasts, without the presence of T cells. These findings demonstrate
       that progressive joint destruction in RA can occur in the absence of T
       cells. Moreover, our results support the hypothesis that both T
       cell-dependent and T cell-independent pathways play a significant role
       in the pathogenesis of RA.
 DE    Arthritis, Rheumatoid/*COMPLICATIONS/*PATHOLOGY  Case Report  Human  HIV
       Infections/*COMPLICATIONS  Immunohistochemistry  Joints/*PATHOLOGY  Male
       Middle Age  Support, Non-U.S. Gov't  Synovial Membrane/PATHOLOGY
       JOURNAL ARTICLE

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