Document 0045
 DOCN  M9610045
 TI    Modulation of T-cell adhesion markers, and the CD45R and CD57 antigens
       in human alcoholics.
 DT    9601
 AU    Cook RT; Ballas ZK; Waldschmidt TJ; Vandersteen D; LaBrecque DR; Cook
       BL; Department of Pathology, Veteran's Affairs Medical Center, Iowa;
       City, Iowa 52246, USA.
 SO    Alcohol Clin Exp Res. 1995 Jun;19(3):555-63. Unique Identifier :
       AIDSLINE MED/96028359
 AB    Direct and indirect evidence indicates that T cells are altered in
       alcoholics. The most commonly reported changes under direct examination
       have been consistent with an increased level of activation as reflected
       by shifts in the ratio of common leukocyte antigen isoforms expressed at
       the cell surface, by increases in the expression of class II antigen, or
       by alterations in the expression of various adhesion molecules.
       Functional evidence for T-cell abnormality includes loss of delayed
       hypersensitivity and a number of findings attributed to dysregulation of
       B cells by alcoholic T cells; these include the widely reported
       distrubances of immunoglobulin production in vivo and a range of
       abnormal responses when T and B cells are combined in vitro. Detailed
       flow cytometric examination of T cells from alcoholics with or without
       active liver disease reveals a significant loss of L-selectin CD8+ T
       cells, but not usually of CD4+ T cells. There is an inverse increase in
       the expression of CD11b on the CD8+ cells that have decreased
       L-selectin+ percentages. Both CD8+ and CD4+ T cells in alcoholics
       display a significant loss of the CD45RA isoform and a gain of cells
       exhibiting the CD45RO isoform. Other surface alterations include
       increased expression of CD57, a marker most commonly associated on T
       cells with conditions of chronic increased antigenic exposure. It is
       argued that these and other T-cell alterations in alcoholics are
       cytokine-driven in part and result in T-cell differentiation states that
       are functionally inappropriate.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adult  Alcoholism/*IMMUNOLOGY  Antigens, CD45/*ANALYSIS  Antigens,
       CD57/*ANALYSIS  Cell Adhesion/*IMMUNOLOGY  Cytokines/PHYSIOLOGY  CD4
       Lymphocyte Count  CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Female  Flow Cytometry  Hepatitis,
       Alcoholic/IMMUNOLOGY  Human  Immunophenotyping  Liver Diseases,
       Alcoholic/IMMUNOLOGY  Liver Function Tests  Male  Middle Age  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't,
       P.H.S.  T-Lymphocytes/DRUG EFFECTS/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).