Document 0080
 DOCN  M9610080
 TI    Autoimmunity, apoptosis defects and retroviruses.
 DT    9601
 AU    Mountz JD; Cheng J; Su X; Wu J; Zhou T; University of Alabama,
       Department of Medicine, Birmingham, USA.
 SO    Adv Exp Med Biol. 1995;374:183-201. Unique Identifier : AIDSLINE
       MED/96047248
 AB    Autoimmunity and AIDS both share the common feature of increased
       expression of retroviral protein products and abnormal apoptosis of
       immune cells (81). This leads to a more global immunomodulatory defect
       (82-84). The challenge in the future will be to devise compounds that
       can either regulate the effect of the retroviral products on apoptosis,
       or that can inhibit apoptosis pathways in order to restore normal immune
       system function.
 DE    Amino Acid Sequence  Animal  Antigens, CD95  Apoptosis/*IMMUNOLOGY
       *Autoimmunity  Base Sequence  Human  Mice  Molecular Sequence Data
       Point Mutation  Retrotransposons  Retroviridae/*IMMUNOLOGY  Support,
       U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).