Document 0132
 DOCN  M9610132
 TI    Risk of dysplasia in anal condyloma.
 DT    9601
 AU    Metcalf AM; Dean T; Department of Surgery, University of Iowa Hospital,
       Iowa City; 52242-1086, USA.
 SO    Surgery. 1995 Oct;118(4):724-6. Unique Identifier : AIDSLINE
       MED/96006378
 AB    BACKGROUND. Recent studies suggest an alarming incidence of dysplasia in
       homosexuals with anal condyloma. The purpose of our study was to
       determine the incidence of dysplasia in anal condyloma in our male
       patients and to determine risk factors for premalignant or malignant
       change. METHODS. Between 1986 and 1994, 103 male patients were referred
       to our colorectal clinic for evaluation of anal condyloma. Ninety-one
       patients had biopsy for pathology and form the basis of this report. All
       charts were reviewed and results analyzed using the chi-squared test
       with the Yates correction factor. RESULTS. Mean patient age was 31 +/-
       11 years (range, 13 to 78 years) and mean duration of disease was 20 +/-
       26 months (range, 2 to 120 months). There were 59 heterosexuals and 32
       homosexuals/bisexuals. Two heterosexuals (3%) had invasive squamous cell
       carcinoma and four (6%) had dysplasia. One homosexual/bisexual (3%) had
       squamous cell carcinoma in situ and nine (28%) had dysplasia (p < 0.05).
       Statistical analysis revealed that HIV seropositive status and disease
       location above the dentate line also predicted increased risk of
       dysplasia, whereas duration of disease, previous topical therapy,
       substance abuse, and other sexually transmitted diseases were not
       significant risk factors. CONCLUSIONS. Homosexual orientation, disease
       above the dentate line and HIV seropositivity increase the risk of
       dysplasia in perianal condyloma. The incidence of dysplasia in perianal
       condyloma is significant enough to warrant consideration of biopsy in
       all patients.
 DE    Adolescence  Adult  Aged  Anus/*PATHOLOGY  Anus
       Neoplasms/*EPIDEMIOLOGY/PATHOLOGY  Biopsy  Carcinoma in
       Situ/*EPIDEMIOLOGY  Carcinoma, Squamous Cell/*EPIDEMIOLOGY  Comorbidity
       Condylomata Acuminata/*PATHOLOGY  Epithelium/PATHOLOGY  Human  HIV
       Infections/EPIDEMIOLOGY  Male  Middle Age  Papillomavirus/PATHOGENICITY
       Precancerous Conditions/*PATHOLOGY  Retrospective Studies  Sex Behavior
       Sexually Transmitted Diseases/EPIDEMIOLOGY  Substance Abuse/EPIDEMIOLOGY
       Tumor Virus Infections  JOURNAL ARTICLE  REVIEW  REVIEW, MULTICASE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).