Document 0163
 DOCN  M9610163
 TI    [Clinical characteristics and natural history of human immunodeficiency
       virus infection. Study in a Chilean population served at a
       multiprofessional pilot center]
 DT    9601
 AU    Wolff M; Northland R; Segovia J; Beltran C; Valdes M; Albornoz M;
       Allendes G; Departamento de Medicina, Facultad de Medicina, Universidad
       de; Chile, Santiago de Chile.
 SO    Rev Med Chil. 1995 Jan;123(1):61-73. Unique Identifier : AIDSLINE
       MED/96054121
 AB    Four hundred and eighty six infected adults (90.7% men) were
       prospectively followed from 1988 to 1993 at a multiprofessional center
       in Santiago, Chile. 87.8% of male patients (pts)--84% of them
       homo/bisexual--and 64.4% of women acquired the infection sexually. At
       the beginning of the follow up (F/U) 51% of men and 71% of women were
       asymptomatic and 30% of the total group had AIDS. (AIDS definition: CDC
       1993, excluded CD4 lymphocyte count < 200 x mm3). 240/486 (49.4%) had
       developed AIDS at the end of the study (12/31/93). AIDS defining events
       (ADE) were: interstitial pneumonia (confirmed or suggestive as caused by
       P. carinii [PCP]), 25%; tuberculosis (all forms), 22.1%; wasting, 13.8%;
       Kaposi Sarcoma, 9.2%; esophageal candidiasis, 6.7%; isosporiasis, 5.4%.
       Of all PCP cases, 72% were ADE, the rest, post.AIDS'. As expected, AIDS
       pts continued having major complications (mainly bacterial pneumonias,
       PCPs, esophagitis, tuberculosis and diarrhea due to I. belli and
       Cryptosporidium. Less frequently, but also observed, were toxoplasmic
       encephalitis and cryptococcal meningitis). Known mortality (excluded
       abandonment of F/U) was 27% for the whole group and varied from 5.8%,
       51.6% to 69.2% for the first, 4th and 6th year of F/U respectively. For
       II-III CDC pts the mortality was 5% and 57% and for IV CDC pts it was
       38% and 100% during the first and 6th year of F/U respectively. 36%,
       53%, 74% and 85% of the pts followed for 1, 3, 5 and 6 years
       respectively had developed AIDS by the end of 1993. Multifactorial
       causes with either diarrhea, wasting or both were responsible for the
       death in half the pts in whom this was known, 15% died of respiratory
       complications and 5.7% of cryptococcal meningitis. 80% of AIDS pts
       survived their ADE. This study has provided information about the
       clinical profile of the HIV infection and natural history of the disease
       in Chile.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*DIAGNOSIS/
       MORTALITY/TRANSMISSION  Adult  Chile/EPIDEMIOLOGY  Community Health
       Centers  English Abstract  Female  Follow-Up Studies  Human  HIV
       Infections/COMPLICATIONS/*DIAGNOSIS/MORTALITY/TRANSMISSION  Male  Middle
       Age  Patient Care Team  Pilot Projects  Prospective Studies  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).