Document 0168
 DOCN  M9610168
 TI    Bronchiolitis obliterans organizing pneumonia.
 DT    9601
 AU    Epler GR; Department of Medicine, New England Baptist Hospital, Boston,
       MA; 02120, USA.
 SO    Semin Respir Infect. 1995 Jun;10(2):65-77. Unique Identifier : AIDSLINE
       MED/96047398
 AB    Bronchiolitis obliterans organizing pneumonia (BOOP) is increasingly
       recognized as an important cause of diffuse infiltrative lung disease.
       It is a diagnostic consideration in patients with a febrile flu-like
       illness of a few weeks' duration and a roentgenogram showing bilateral
       patchy infiltrates that are not responsive to a typical course of
       antibiotics. It is defined as granulated tissue plugs within lumens of
       small airways that extend into alveolar ducts and alveoli. Clinically, a
       flu-like illness, cough, and crackles are common. Pulmonary function
       studies of patients show a decreased vital capacity, normal flow rates
       (except in smokers), and a decreased diffusing capacity. It is generally
       idiopathic, but it may occur during the resolution of a viral or
       mycoplasma pneumonia. It is also associated with a variety of systemic
       illnesses and clinical settings. These include the connective tissue
       disorders, antineoplastic and other drugs, and immunological disorders,
       as well as bone marrow and lung transplantation. There are numerous
       related disorders, including human immunodeficiency virus infection,
       radiation therapy, thyroiditis, and alcoholic cirrhosis. In idiopathic
       BOOP, complete resolution occurs in 65% to 85% of patients treated with
       corticosteroid therapy. This type of therapy is often effective in
       patients with associated systemic disorders or in other clinical
       settings, but there may be limited or no response in patients with
       dermatomyositis, immunosuppression, or interstitial opacities at the
       lung bases. Respiratory failure leading to death may occur in 5% of
       patients. It is important to add BOOP to the differential diagnosis of
       febrile, noninfectious illnesses that are mimics of pneumonia.
 DE    Adult  Arthritis, Rheumatoid/COMPLICATIONS  Bone Marrow
       Transplantation/ADVERSE EFFECTS  Bronchiolitis Obliterans Organizing
       Pneumonia/CLASSIFICATION/  *DIAGNOSIS/ETIOLOGY  Connective Tissue
       Diseases/COMPLICATIONS  Diagnosis, Differential  Female  Human
       Immunologic Diseases/COMPLICATIONS  Lung/PATHOLOGY  Lung
       Transplantation/ADVERSE EFFECTS  Male  Middle Age  Pneumonia/DIAGNOSIS
       Pneumonia, Mycoplasma/COMPLICATIONS  Pneumonia, Viral/COMPLICATIONS
       Thoracic Radiography  Tomography, X-Ray Computed  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).