Document 0174
 DOCN  M9610174
 TI    Apoptosis parallels lymphopoiesis in bone marrow transplantation and HIV
       disease.
 DT    9601
 AU    Donnenberg AD; Margolick JB; Beltz LA; Donnenberg VS; Rinaldo CR Jr;
       University of Pittsburgh School of Medicine, Department of; Medicine,
       PA, 15213 USA.
 SO    Res Immunol. 1995 Jan;146(1):11-21. Unique Identifier : AIDSLINE
       MED/96053385
 AB    Apoptosis has been implicated in a variety of physiological processes
       ranging from tissue modeling to deletion of autoreactive T lymphocytes
       during thymic development. The recent finding that a large proportion of
       peripheral T cells from HIV-infected subjects (corrected from subjects)
       apoptose in culture raises an important issue: does this represent a
       pathologic mechanism by which the virus disrupts the immune system, or a
       normal physiologic response to virus-mediated T-cell loss? To study the
       potential relationship between apoptosis and lymphopoiesis, we compared
       apoptosis rates in unstimulated lymphocyte cultures from healthy
       subjects, HIV+ gay men, and bone marrow transplant (BMT) recipients
       undergoing immune reconstruction. BMT recipients were chosen because
       they undergo massive regeneration of lymphocytes following marrow
       ablation and graft infusion. The data obtained in BMT recipients
       suggests that elevated apoptosis accompanies, and is the consequence of,
       elevated lymphopoiesis. We also found a strong inverse relationship
       between in vitro T-cell apoptosis rates and peripheral T-cell counts.
       These results provide new interpretation for elevated apoptosis observed
       in HIV-infected individuals--that it reflects increased T-cell turnover
       consequent to virus-mediated destruction of CD4+ T-cells.
 DE    Apoptosis/*IMMUNOLOGY  Bone Marrow Transplantation/*IMMUNOLOGY
       Comparative Study  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY
       Hematopoiesis/*IMMUNOLOGY  Human  HIV Infections/BLOOD/*IMMUNOLOGY  Male
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

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