Document 0206
 DOCN  M9610206
 TI    Association of hepatic veno-occlusive disease with the acquired
       immunodeficiency syndrome.
 DT    9601
 AU    Buckley JA; Hutchins GM; Department of Pathology, Johns Hopkins Medical
       Institutions,; Baltimore, Maryland, USA.
 SO    Mod Pathol. 1995 May;8(4):398-401. Unique Identifier : AIDSLINE
       MED/96053500
 AB    AIMS: Observation of a patient with the acquired immunodeficiency
       syndrome and veno-occlusive disease (VOD) at autopsy prompted us to
       review the liver pathology of autopsied patients with human
       immunodeficiency virus seropositivity and/or acquired immunodeficiency
       syndrome (HIV/AIDS) to determine the frequency of occurrence of VOD and
       the circumstances in which it arose. METHODS: the patients studied had
       been autopsied at The Johns Hopkins Hospital, a referral center, between
       April 1981 and July 1993. We reviewed 275 adult HIV/AIDS patients
       autopsied with liver slides available for evaluation. Twenty cases
       fulfilled the pathologic criteria for VOD, central vein obliteration and
       sclerosis, sinusoidal congestion and fibrosis, and perivenular
       hepatocellular degeneration and necrosis. The autopsy cases were
       compared for age, race, gender, duration of HIV infection, and risk
       factor for the acquisition of HIV infection. The clinical and pathologic
       features of the 20 cases with VOD were reviewed. RESULTS: of the 275
       HIV/AIDS patients, 20 (7.3%) had VOD. The average age was 41 yr (range
       30-58) and most cases were black males (15 black, 5 white, and 18 male).
       The duration of HIV infection ranged from 6 mo to 8 yr (mean, 19 mo).
       The risk factor for acquiring HIV infection was primarily intravenous
       drug abuse (12 of 20, 60%). Six patients had homosexual or bisexual
       contacts, and two had other or unknown risk factors. In contrast, among
       the total of 275 HIV/AIDS autopsied patients reviewed, only 72 (26%)
       reported intravenous drug abuse whereas 157 (57%) individuals listed
       homosexual or bisexual contacts as a risk for developing HIV infection.
       Forty-six patients (17%) had other or unknown means of HIV infection.
       Statistical analysis by risk factor showed that intravenous drug abuse
       was statistically significant as a predictor for the development of VOD
       in an HIV/AIDS patient (P < 0.005). CONCLUSIONS: VOD of the liver can be
       seen in patients with HIV/AIDS and is associated with intravenous drug
       abuse.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/*PATHOLOGY  Adult  Aged
       Female  Hepatic Veno-Occlusive Disease/EPIDEMIOLOGY/*PATHOLOGY  Human
       Liver/PATHOLOGY  Male  Middle Age  Substance Abuse,
       Intravenous/EPIDEMIOLOGY/*PATHOLOGY  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).