Document 0291
 DOCN  M9610291
 TI    Adult T cell leukemia following HTLV-I-associated myelopathy/tropical
       spastic paraparesis: case reports and implication to the natural course
       of ATL.
 DT    9601
 AU    Tamiya S; Matsuoka M; Takemoto S; Shimizu K; Yamaguchi K; Mita S; Uchino
       M; Ando M; Miyaguni T; Kuniyoshi K; et al; Second Department of Internal
       Medicine, Kumamoto University; School of Medicine, Japan.
 SO    Leukemia. 1995 Oct;9(10):1768-70. Unique Identifier : AIDSLINE
       MED/96013980
 AB    Adult T cell leukemia (ATL) is the T cell malignancy caused by human T
       lymphotropic virus type I (HTLV-I), and HTLV-I is also the causative
       agent of HTLV-I-associated myelopathy/tropical spastic paraparesis
       (HAM/TSP). Although HTLV-I causes both diseases, concomitant occurrence
       is reported to be rare. This paper describes two cases of HAM/TSP that
       developed into lymphoma-type ATL after the onset of HAM/TSP. In one
       case, the same HTLV-I infected clone could be detected by polymerase
       chain reaction in peripheral blood obtained when the patient was
       diagnosed as HAM/TSP. This finding showed that the HTLV-I clone already
       existed at the stage of HAM/TSP. Since frequent detection of clonal
       proliferation of HTLV-I infected cells has been reported previously in
       patients with HAM/TSP, careful follow-up is needed for patients with
       HAM/TSP.
 DE    Base Sequence  Case Report  Disease Progression  Female  Human
       HTLV-I/GENETICS/*ISOLATION & PURIF  Leukemia, T-Cell/PATHOLOGY/*VIROLOGY
       Male  Middle Age  Molecular Sequence Data  Paraparesis, Tropical
       Spastic/PATHOLOGY/*VIROLOGY  Polymerase Chain Reaction  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

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