Document 0363
 DOCN  M9610363
 TI    Detection of several types of human papilloma viruses in AIDS-associated
       Kaposi's sarcoma.
 DT    9601
 AU    Adams V; Kempf W; Hassam S; Briner J; Schmid M; Moos R; Pfaltz M;
       Department of Pathology, University of Zurich, Switzerland.
 SO    J Med Virol. 1995 Jul;46(3):189-93. Unique Identifier : AIDSLINE
       MED/96028706
 AB    Epidemiological studies indicate that acquired immunodeficiency syndrome
       (AIDS)-associated Kaposi's sarcoma (KS) may be caused by an infectious,
       preferentially sexually transmitted agent. Infections with human
       papilloma viruses are common, sexually transmitted diseases occurring
       frequently in homosexual men, who are also the main risk group for
       developing KS. In order to evaluate the possible role of HPV in the
       development of KS, 24 cutaneous AIDS-associated Kaposi's sarcomas were
       investigated by the polymerase chain reaction (PCR) and by in situ
       hybridization for the presence of human papilloma viruses (HPV). HPV DNA
       sequences were detected in 5 of 24 KS specimens, in 4 of 13 normal skin
       specimens from AIDS patients without KS and in 5 of 14 skin specimens of
       HIV-seronegative patients. For the first time, HPV types 6 and 33 were
       detected by PCR in KS. A higher proportion of HPV types 16/18 was found
       in AIDS-associated KS specimens, whereas HPV type 33 was seen more often
       in normal skin specimens of the control group. Apart from the known HPV
       types 16/18 described in KS, this study demonstrates also the presence
       of HPV 6 and 33 in this condition.
 DE    Adult  Aged  AIDS-Related Opportunistic
       Infections/COMPLICATIONS/*VIROLOGY  Base Sequence  DNA Primers  DNA,
       Viral/ANALYSIS  Human  In Situ Hybridization  Male  Middle Age
       Molecular Sequence Data  Papillomavirus, Human/CLASSIFICATION/*ISOLATION
       & PURIF  Papovaviridae Infections/COMPLICATIONS/PATHOLOGY/*VIROLOGY
       Sarcoma, Kaposi's/COMPLICATIONS/PATHOLOGY/*VIROLOGY  Tumor Virus
       Infections/COMPLICATIONS/PATHOLOGY/*VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).