Document 0363 DOCN M9610363 TI Detection of several types of human papilloma viruses in AIDS-associated Kaposi's sarcoma. DT 9601 AU Adams V; Kempf W; Hassam S; Briner J; Schmid M; Moos R; Pfaltz M; Department of Pathology, University of Zurich, Switzerland. SO J Med Virol. 1995 Jul;46(3):189-93. Unique Identifier : AIDSLINE MED/96028706 AB Epidemiological studies indicate that acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS) may be caused by an infectious, preferentially sexually transmitted agent. Infections with human papilloma viruses are common, sexually transmitted diseases occurring frequently in homosexual men, who are also the main risk group for developing KS. In order to evaluate the possible role of HPV in the development of KS, 24 cutaneous AIDS-associated Kaposi's sarcomas were investigated by the polymerase chain reaction (PCR) and by in situ hybridization for the presence of human papilloma viruses (HPV). HPV DNA sequences were detected in 5 of 24 KS specimens, in 4 of 13 normal skin specimens from AIDS patients without KS and in 5 of 14 skin specimens of HIV-seronegative patients. For the first time, HPV types 6 and 33 were detected by PCR in KS. A higher proportion of HPV types 16/18 was found in AIDS-associated KS specimens, whereas HPV type 33 was seen more often in normal skin specimens of the control group. Apart from the known HPV types 16/18 described in KS, this study demonstrates also the presence of HPV 6 and 33 in this condition. DE Adult Aged AIDS-Related Opportunistic Infections/COMPLICATIONS/*VIROLOGY Base Sequence DNA Primers DNA, Viral/ANALYSIS Human In Situ Hybridization Male Middle Age Molecular Sequence Data Papillomavirus, Human/CLASSIFICATION/*ISOLATION & PURIF Papovaviridae Infections/COMPLICATIONS/PATHOLOGY/*VIROLOGY Sarcoma, Kaposi's/COMPLICATIONS/PATHOLOGY/*VIROLOGY Tumor Virus Infections/COMPLICATIONS/PATHOLOGY/*VIROLOGY JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).