Document 0406
 DOCN  M9610406
 TI    Rapid rejection of H2k and H2k/b bone marrow cell grafts by CD8+ T cells
       and NK cells in irradiated mice.
 DT    9601
 AU    Davenport C; Kumar V; Bennett M; Department of Pathology, University of
       Texas Southwestern Medical; Center, Dallas, TX 75235, USA.
 SO    J Immunol. 1995 Oct 15;155(8):3742-9. Unique Identifier : AIDSLINE
       MED/96003411
 AB    Acute rejection of transplanted bone marrow cell (BMC) grafts can occur
       within 48 h in unsensitized, lethally irradiated mice, and NK cells have
       been implicated as the effector cells. Recently, we observed that both
       CD8+ TCR-alpha beta+ T and NK cells of irradiated mice could rapidly
       reject allogeneic lymph node cell grafts. In this study, we evaluated
       the ability of NK and CD8+ T cells to mediate rejection of H2k or H2k/b
       BMC grafts by pretreating groups of mice with depleting mAbs. H2k BMC
       were transplanted into syngeneic, B6 (H2b), BALB/c (H2d), NZB (H2d), and
       (NZB x B6)F1 (NZB6F1, H2d/b) hosts. Proliferation measured 5 days after
       cell transfer indicated that syngeneic, B6, and BALB/c hosts accepted
       H2k BMC grafts. However, CD8+ T cells from NZB and poly I:C-treated
       BALB/c hosts, and NK cells from poly I:C-treated NZB6F1, hosts, rejected
       H2k BMC grafts. In NZB6F1 hosts, there was an added effect of
       anti-TCR-alpha beta and anti-NK1.1 mAbs. It is possible that T and NK
       cells cooperate in rejecting H2k or H2k/b BMC grafts in certain hosts.
       Transplantation of H2k/b, but not H2k/d, BMC into similar recipients had
       the same fate as H2k BMC. Thus, certain CD8+ T cells may share a similar
       recognition system with NK cells.
 DE    Animal  Bone Marrow Transplantation/*IMMUNOLOGY  Crosses, Genetic
       CD8-Positive T-Lymphocytes/*IMMUNOLOGY  *Graft Rejection  H-2
       Antigens/GENETICS/*IMMUNOLOGY  Killer Cells, Natural/*IMMUNOLOGY  Mice
       Mice, Inbred BALB C  Mice, Inbred CBA  Mice, Inbred C57BL  Mice, Inbred
       NZB  Radiation Chimera  Receptors, Antigen, T-Cell,
       alpha-beta/IMMUNOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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