Document 0407
 DOCN  M9610407
 TI    T cell development in CD8-/- mice. Thymic positive selection is biased
       toward the helper phenotype.
 DT    9601
 AU    Bachmann MF; Oxenius A; Mak TW; Zinkernagel RM; Department of Pathology,
       University of Zurich, Switzerland.
 SO    J Immunol. 1995 Oct 15;155(8):3727-33. Unique Identifier : AIDSLINE
       MED/96003409
 AB    The CD4 and CD8 molecules are involved in T cell differentiation and
       activation. Nevertheless, efficient thymic maturation of helper T cells
       has been shown in the absence of the CD4 molecule. These CD4-deficient
       helper T cells expressed alpha beta-TCR and were able to control
       Leishmania infections and to mediate Ab class switch. Using mice
       deficient for the CD8 alpha-chain, we investigated whether a similar
       cytotoxic T cell population was generated in the absence of the CD8
       coreceptor. A CD8-deficient cytotoxic T cell population corresponding to
       the described CD4-deficient helper T cell population was virtually
       absent both functionally and physically. These results support the idea
       that thymic maturation is asymmetrical and strongly biased toward the
       helper phenotype.
 DE    Animal  Cell Differentiation/GENETICS/IMMUNOLOGY  Cytotoxicity Tests,
       Immunologic  CD8-Positive T-Lymphocytes/*IMMUNOLOGY  Flow Cytometry
       Histocompatibility Antigens Class I/GENETICS  Histocompatibility
       Antigens Class II/GENETICS  Isoantigens/GENETICS  Lymphocyte
       Transformation/IMMUNOLOGY  Lymphocytic Choriomeningitis Virus/IMMUNOLOGY
       Mice  Mice, Inbred C57BL  Mice, Mutant Strains  Phenotype  Support,
       Non-U.S. Gov't  T-Lymphocytes, Helper-Inducer/*IMMUNOLOGY  Vesicular
       Stomatitis-Indiana Virus/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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