Document 0495
 DOCN  M9610495
 TI    [Pregnancies in HIV infected women in Switzerland]
 DT    9601
 AU    Biedermann K; Rudin C; Irion O; Spoletini G; Lauper U; Kind C;
       Kantonales Frauenspital Fontana, Chur.
 SO    Geburtshilfe Frauenheilkd. 1995 Aug;55(8):447-55. Unique Identifier :
       AIDSLINE MED/96024309
 AB    In a national multicentre study, 229 pregnancies in 219 HIV-positive
       women were prospectively followed up between January 1, 1990, and
       October 30, 1993. 69.8% were infected by intravenous drug abuse and
       91.5% were asymptomatic (CDC classes II and III) in early pregnancy. 48
       (21.0%) were first discovered to be HIV-infected during the index
       pregnancy: 46 of these had risk factors. The present epidemiologic
       development does not seem to warrant a general HIV-screening in
       pregnancy at this time. 71 pregnancies (31%) were terminated; 158
       children were born, 17 (23.3%) of the 73 definitely classified are
       HIV-infected. An asymptomatic HIV infection with a sufficiently high (>
       200/microliters) CD4 cell count has no proven influence on the
       pregnancy. Otherwise, however, maternal infectious diseases can lead to
       prematurity. For mothers with i.v. drug abuse, there is a significantly
       higher incidence of prematurity and fetal growth retardation. The
       maternal HIV infection can be transmitted to the child either during
       pregnancy or at delivery. The incidence of vertical transmission in our
       study was 23.3%; the most predictive parameter for a prenatal HIV
       transmission is a low anti-p24 antibody titre. The risk of intrapartum
       transmission seems to be somewhat, but not significantly, reduced for
       primary Caesarean sections. Recently, prophylaxis with Zidovudin during
       pregnancy, beginning after the 14th GW, was found to reduce vertical
       HIV-transmission by 66%. Since the virus can also be transmitted through
       mothers' milk, HIV-positive mothers should not nurse their babies.
       Maternal infections are significantly more frequent in HIV-positive
       women, and are a risk factor for prematurity.(ABSTRACT TRUNCATED AT 250
       WORDS)
 DE    Abortion, Induced/STATISTICS & NUMER DATA  Adult  Cesarean
       Section/STATISTICS & NUMER DATA  Cross-Sectional Studies  CD4 Lymphocyte
       Count/DRUG EFFECTS  Disease Transmission, Vertical/PREVENTION & CONTROL
       English Abstract  Female  Human  HIV
       Infections/*EPIDEMIOLOGY/TRANSMISSION  *HIV-1  Incidence  Infant,
       Newborn  Mass Screening  Pregnancy  Pregnancy Complications,
       Infectious/*EPIDEMIOLOGY/ETIOLOGY  Pregnancy Outcome  Risk Factors
       Substance Abuse, Intravenous/COMPLICATIONS/EPIDEMIOLOGY  Support,
       Non-U.S. Gov't  Switzerland/EPIDEMIOLOGY  Zidovudine/ADMINISTRATION &
       DOSAGE/ADVERSE EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).