Document 0500
 DOCN  M9610500
 TI    High-affinity binding of melatonin by human circulating T lymphocytes
       (CD4+).
 DT    9601
 AU    Gonzalez-Haba MG; Garcia-Maurino S; Calvo JR; Goberna R; Guerrero JM;
       Department of Medical Biochemistry and Molecular Biology,; University of
       Seville School of Medicine, Spain.
 SO    FASEB J. 1995 Oct;9(13):1331-5. Unique Identifier : AIDSLINE
       MED/96026200
 AB    This paper shows the presence of high-affinity binding sites for
       melatonin in human circulating T lymphocytes, but not in B lymphocytes.
       The binding of melatonin to T cells was dependent on time, stable,
       reversible, saturable, specific, and inversely correlated to the
       production of melatonin, expressed as the nocturnal 12 h production of
       its urinary metabolite 6-sulfatoxymelatonin. The affinity of these
       binding sites (Kd = 0.27 nM) suggests that they may recognize the
       physiological concentrations of melatonin in serum. Moreover, among the
       lymphocyte subpopulations studied, binding of melatonin was mostly found
       in CD4+ cells rather than in CD8+ cells. Results suggest that CD4+ cells
       may be the target of melatonin among the human circulating lymphocytes.
 DE    Adult  B-Lymphocytes/METABOLISM  CD4-Positive T-Lymphocytes/*METABOLISM
       CD8-Positive T-Lymphocytes/METABOLISM  Human  Melatonin/ANALOGS &
       DERIVATIVES/*METABOLISM/URINE  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).