Document 0540
 DOCN  M9610540
 TI    Synthesis of protegrin-related peptides and their antibacterial and
       anti-human immunodeficiency virus activity.
 DT    9601
 AU    Tamamura H; Murakami T; Horiuchi S; Sugihara K; Otaka A; Takada W; Ibuka
       T; Waki M; Yamamoto N; Fujii N; Faculty of Pharmaceutical Sciences,
       Kyoto University, Japan.
 SO    Chem Pharm Bull (Tokyo). 1995 May;43(5):853-8. Unique Identifier :
       AIDSLINE MED/96044342
 AB    All disulfide analogs (types I, II and III) of protegrin (PG)-1, an
       18-residue antimicrobial peptide having two intramolecular disulfide
       bonds, were synthesized using regioselective disulfide bond formation.
       Random air-oxidation of the fully reduced PG-1 formed the type III PG-1.
       In addition, a type III analog containing an amidated carboxy-terminal
       residue was also prepared. Each analog showed significant and different
       antibacterial and anti-human immunodeficiency virus (HIV) activity.
       Deletion of two disulfide bridges caused a significant decrease in
       activity.
 DE    Amino Acid Sequence  Animal  Anti-Infective Agents/*CHEMICAL
       SYNTHESIS/*PHARMACOLOGY  Antiviral Agents/*CHEMICAL
       SYNTHESIS/*PHARMACOLOGY  Candida albicans/DRUG EFFECTS
       Disulfides/CHEMICAL SYNTHESIS/PHARMACOLOGY  Escherichia coli/DRUG
       EFFECTS  Human  HIV/*DRUG EFFECTS  Microbial Sensitivity Tests
       Molecular Sequence Data  Peptides/*CHEMICAL SYNTHESIS/*PHARMACOLOGY
       Proteins/*CHEMICAL SYNTHESIS/*PHARMACOLOGY  Salmonella/DRUG EFFECTS
       Sequence Homology, Amino Acid  Structure-Activity Relationship  JOURNAL
       ARTICLE

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