Document 0546
 DOCN  M9610546
 TI    Chancroid and Haemophilus ducreyi: an update.
 DT    9601
 AU    Trees DL; Morse SA; Division of Sexually Transmitted Disease, Centers
       for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.
 SO    Clin Microbiol Rev. 1995 Jul;8(3):357-75. Unique Identifier : AIDSLINE
       MED/96009213
 AB    Haemophilus ducreyi is a fastidious gram-negative bacillus that causes
       the sexually transmitted infection chancroid. Chancroid is a major
       genital ulcerative disease in Africa, Southeast Asia, the Caribbean, and
       Latin America and is of increasing concern in the United States. Genital
       ulcerative disease and chancroid in particular have been associated with
       facilitating the transmission of human immunodeficiency virus. The
       diagnosis of chancroid based on the clinical appearance of the genital
       lesion or on the isolation of H. ducreyi on selective medium is
       relatively insensitive. However, recent advances in nonculture
       diagnostic tests have enhanced our ability to diagnose chancroid. There
       has been renewed interest in understanding the pathogenesis of H.
       ducreyi. In vitro and in vivo models have been developed to help
       identify important virulence determinants. Through the use of
       biochemical and molecular techniques, macromolecular components that may
       be important in virulence have been identified.
 DE    Animal  Antibody Formation  Bacterial Typing Techniques
       Chancroid/*DIAGNOSIS/DRUG THERAPY/EPIDEMIOLOGY/*MICROBIOLOGY  Culture
       Media/CHEMISTRY  Forecasting  Haemophilus ducreyi/*CLASSIFICATION/DRUG
       EFFECTS/GROWTH &  DEVELOPMENT/*PATHOGENICITY  Human  Microbial
       Sensitivity Tests  Virulence  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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