Document 0569
 DOCN  M9610569
 TI    Use of polyclonal IgG in HIV infection and AIDS.
 DT    9601
 AU    Buscombe JR; Oyen WJ; Corstens FH; Department of Nuclear Medicine, Royal
       Free Hospital, London, UK.
 SO    Q J Nucl Med. 1995 Sep;39(3):212-20. Unique Identifier : AIDSLINE
       MED/96033590
 AB    Nuclear Medicine should have a pivitol role to play in the investigation
       of patients infected with the human immunodeficiency virus (HIV).
       Unfortunately the use of scintigraphic techniques to localise infection
       have not become widely used in Europe. Neither 67Ga citrate or labelled
       leukocytes are ideal. In a search for new agents which can be used to
       identify the presence of infection both 99mTc and 111In labelled
       polyclonal immunoglobulin-C have been investigated. It was found that
       99mTc labelled polyclonal immune-globulin-G was not able to localise
       infection in either the chest or the abdomen. In contrast 111In labelled
       polyclonal immunoglobulin-G had both high sensitivity and specificity
       for imaging infection in HIV infected patients. If these preliminary
       results are confirmed immunoglobulin-G could find an important clinical
       application in this specialised patient group.
 DE    AIDS-Related Opportunistic Infections/*DIAGNOSIS  Human  IgG/*DIAGNOSTIC
       USE  Indium Radioisotopes/*DIAGNOSTIC USE  Technetium/*DIAGNOSTIC USE
       JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

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