Document 0588
 DOCN  M9610588
 TI    Immunologic and virologic markers determining progression to AIDS.
 DT    9601
 AU    Schellekens PT; Koot M; Roos MT; Tersmette M; Miedema F; Department of
       Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red
       Cross Blood Transfusion Service, Amsterdam.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 2:S62-6.
       Unique Identifier : AIDSLINE MED/96033814
 AB    Infection with the human immunodeficiency virus type 1 (HIV-1) results
       in a severe immunodeficiency characterized by a depletion of CD4+
       T-helper cells. Furthermore, it is well documented that in asymptomatic
       persons the number of CD4+ cells is also a good predictor of progression
       to AIDS. However, persons with similar CD4+ cell counts may differ with
       regard to clinical progression. For this reason the development of
       additional markers predictive of disease progression is of major
       clinical importance. In this review three additional progression markers
       are discussed: rate of decline of CD4+ cells, T-cell reactivity, and HIV
       biological phenotype. Besides their usefulness as independent
       progression markers they also provided insight into immunopathologic
       mechanisms responsible for the eventual development of AIDS.
 DE    *Acquired Immunodeficiency Syndrome/DRUG THERAPY/IMMUNOLOGY/  VIROLOGY
       Antiviral Agents/THERAPEUTIC USE  Biological Markers  CD4 Lymphocyte
       Count  Disease Progression  Human  *HIV-1/IMMUNOLOGY/PHYSIOLOGY
       Prognosis  T-Lymphocytes/IMMUNOLOGY  Zidovudine/THERAPEUTIC USE  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).