Document 0635
 DOCN  M9610635
 TI    Longitudinal immunological follow-up of HIV infected haemophiliacs in
       Hungary.
 DT    9601
 AU    Ujhelyi E; Krall G; Zimonyl I; Banhegyi D; Hollan SR; Horvath A; Fuchs
       D; Wachter H; Berkessy E; Fust G; National Institute of Haematology,
       Blood Transfusion and; Immunology, Budapest, Hungary.
 SO    Acta Microbiol Immunol Hung. 1995;42(2):189-98. Unique Identifier :
       AIDSLINE MED/96044930
 AB    Twenty-five haemophiliacs who had been infected with HIV in 1982 or 1983
       were followed up from 1986 to 1993. The absolute number of the CD4+ and
       CD8+ cells, neopterin levels and more recently the percentage of
       activated, DR+ T lymphocytes were determined twice a year. In most
       patients a permanent decline in the CD4+ cell count was observed whereas
       in two HIV-infected haemophiliacs the absolute number of CD4+ cells did
       not change during the observation period. In these long-term
       non-progressor patients no clinical symptoms and no increased neopterin
       levels were observed. T cells subset and neopterin measurements were
       found to predict the development of AIDS. AIDS developed only in those
       patients who exhibited both a CD4+ cell count of < 350/microliter and a
       serum neopterin concentration of > 20 nmol/l. A negative correlation was
       observed between the percentage of activated. DR+ T lymphocytes and the
       CD4+ cell counts.
 DE    Adolescence  Adult  Antigens, CD3/BIOSYNTHESIS  Biopterin/ANALOGS &
       DERIVATIVES/BIOSYNTHESIS  Case-Control Studies  Child  CD4-CD8 Ratio
       CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Follow-Up Studies
       Hemophilia/COMPLICATIONS/*IMMUNOLOGY/METABOLISM  Human  Hungary  HIV
       Seronegativity/IMMUNOLOGY  HIV
       Seropositivity/COMPLICATIONS/*IMMUNOLOGY/METABOLISM  Lymphocyte
       Subsets/IMMUNOLOGY  Lymphocyte Transformation  Middle Age  Predictive
       Value of Tests  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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