Document 0644
 DOCN  M9610644
 TI    MF59. Design and evaluation of a safe and potent adjuvant for human
       vaccines.
 DT    9601
 AU    Ott G; Barchfeld GL; Chernoff D; Radhakrishnan R; van Hoogevest P; Van
       Nest G; Chiron Corporation, Emeryville, California 94608, USA.
 SO    Pharm Biotechnol. 1995;6:277-96. Unique Identifier : AIDSLINE
       MED/96057688
 AB    MF59 is a safe, practical, and potent adjuvant for use with human
       vaccines. The formulation is easily manufactured, may be sterilized by
       filtration, and is both compatible and efficacious with all antigens
       tested to date. MF59 has been shown to be a potent stimulator of
       cellular and humoral responses to subunit antigens in both animal models
       and clinical studies. Toxicology studies in animal models and Phase
       I-III studies in humans have demonstrated the safety of MF59 with HSV,
       HIV, and influenza vaccines.
 DE    Adjuvants, Immunologic/CHEMISTRY/*CHEMICAL SYNTHESIS  Animal  Drug
       Design  Emulsions  Human  Polysorbates/CHEMISTRY/*CHEMICAL SYNTHESIS
       Squalene/CHEMISTRY/*CHEMICAL SYNTHESIS/IMMUNOLOGY
       Vaccines/ADMINISTRATION & DOSAGE/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).