Document 0673
 DOCN  M9610673
 TI    Analysis of bronchoalveolar lavage cells in chronic eosinophilic
       pneumonia before and during corticosteroid therapy.
 DT    9601
 AU    Takahashi H; Arakawa Y; Oki K; Sugita H; Sakamoto S; Kawabata Y;
       Fukujuji Hospital, Japan Anti-TB Association, Tokyo.
 SO    Int Arch Allergy Immunol. 1995;108 Suppl 1:2-5. Unique Identifier :
       AIDSLINE MED/96011675
 AB    Bronchoalveolar lavage was performed in patients with chronic
       eosinophilic pneumonia of unknown origin diagnosed histopathologically,
       and the alveolar fluid cells were investigated before and during
       corticosteroid therapy. The counts of eosinophils in bronchoalveolar
       lavage fluid decreased markedly during steroid therapy compared with
       before therapy, and the ratios of interleukin 2 receptor-positive T
       cells and HLA DR-positive T cells to all T lymphocytes in the lavage
       fluid also decreased. Both before and during steroid therapy, many
       macrophages in bronchoalveolar lavage fluid phagocytosed EG2-positive
       granules and stained immunohistochemically as CD71-positive 'responsive
       macrophages'. The decrease of activated T lymphocytes and the active
       phagocytosis of eosinophil granules by macrophages might play an
       important role in the mechanism of healing in chronic eosinophilic
       pneumonia.
 DE    Adult  Antigens, CD/ANALYSIS  Antigens, Differentiation,
       B-Lymphocyte/ANALYSIS  Bronchoalveolar Lavage Fluid/*CYTOLOGY  Case
       Report  CD4-CD8 Ratio  Eosinophils/CHEMISTRY  Female  Human  HLA-DR
       Antigens/ANALYSIS  Middle Age  Pulmonary Eosinophilia/*PATHOLOGY
       Receptors, Interleukin-2/ANALYSIS  JOURNAL ARTICLE

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