Document 0679
 DOCN  M9610679
 TI    [The clinical and immunological correlations between the p24 antigenemia
       levels and those of anti-p24 antibodies in HIV-seropositive children]
 DT    9601
 AU    Apetrei C; Buzdugan I; Mitroi I; Duca M; Laboratorul de Virologie,
       U.M.F. Iasi.
 SO    Bacteriol Virusol Parazitol Epidemiol. 1995 Apr-Jun;40(2):141-4. Unique
       Identifier : AIDSLINE MED/96029120
 AB    The influence of HIV I p24 antigen immune complexing with anti-p24
       antibodies of the assessment of their respective levels in HIV-positive
       sera was studied. ELISA tests were used for evaluating anti-p24 and p24
       antigenemia, with or without acid dissociation. We have observed that:
       1. p24 antigenemia usually coexisted with low anti-p24 levels, an
       inverse correlation between these two parameters being traced; acid
       dissociation increased the percentage of p24 positive sera, especially
       when anti-p24 titers are low; 2. on contrary, after acid dissociation,
       p24 Ag remain undetectable in 55.56% of patients presenting high titers
       and 29.41% of those with low levels of anti-p24; acid dissociation do
       not increase anti-p24 titers. Whereas the first group of observations
       suggests that p24 Ag and anti-p24 Ab may be involved in immune
       complexes, the second set indicates that p24 Ag and Ab were not
       inevitably linked in such complexes. So, they may be indicative for two
       distinct biological phenomena.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Chi-Square Distribution
       Child  English Abstract  Enzyme-Linked Immunosorbent
       Assay/METHODS/STATISTICS & NUMER DATA  Human  HIV Antibodies/*BLOOD  HIV
       Core Protein p24/*BLOOD/IMMUNOLOGY  HIV Seropositivity/*IMMUNOLOGY
       HIV-1/*IMMUNOLOGY  Regression Analysis  JOURNAL ARTICLE

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