Document 0687
 DOCN  M9610687
 TI    Cell death in health and disease: the biology and regulation of
       apoptosis.
 DT    9601
 AU    Bellamy CO; Malcomson RD; Harrison DJ; Wyllie AH; Department of
       Pathology, University Medical School, Edinburgh,; UK.
 SO    Semin Cancer Biol. 1995 Feb;6(1):3-16. Unique Identifier : AIDSLINE
       MED/96037771
 AB    Apoptosis is a morphologically stereotyped form of cell death, prevalent
       in multicellular organisms, by which single cells are deleted from the
       midst of living tissues. Recognition of the cellular corpses and their
       removal by phagocytosis occurs without disturbance to tissue
       architecture or function and without initiating inflammation. Apoptosis
       is regulable and is of fundamental importance to tissue development and
       homeostasis. Cellular susceptibility to apoptosis is determined by a
       variety of signals, of both extracellular and internal origin, including
       proliferative status. Dysregulated apoptosis is important in the
       pathogenesis of several important human diseases including neoplasia,
       and recognition of the defects involved is prompting development of new
       therapeutic strategies.
 DE    Acquired Immunodeficiency Syndrome/PATHOLOGY  Animal
       Apoptosis/*PHYSIOLOGY  Cell Death/PHYSIOLOGY  Human
       Inflammation/PATHOLOGY  Neoplasms/PATHOLOGY  Neoplasms,
       Experimental/PATHOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).