Document 0706
 DOCN  M9610706
 TI    Is the human immunodeficiency virus-related Kaposi's sarcoma epidemic
       coming to an end? Insights from the Tricontinental Seroconverter Study.
 DT    9601
 AU    Veugelers PJ; Strathdee SA; Moss AR; Page KA; Tindall B; Schechter MT;
       Coutinho RA; van Griensven GJ; Municpal Health Service, Department of
       Public Health, Amsterdam,; The Netherlands.
 SO    Epidemiology. 1995 Jul;6(4):382-6. Unique Identifier : AIDSLINE
       MED/96039983
 AB    A decline in the proportion of Kaposi's sarcoma among AIDS cases since
       the 1980s has been attributed to changes in sexual behavior among
       homosexual men and a decreasing exposure to a hypothesized Kaposi's
       sarcoma cofactor. Recent studies have shown that the incidence rate of
       Kaposi's sarcoma has remained relatively stable, which seems to argue
       against the hypothesis of a declining exposure to the putative cofactor.
       To examine this paradox, we evaluated the incidence of Kaposi's sarcoma,
       using Cox proportional hazard analyses, and performed a simulation to
       compare incidences of different AIDS outcomes among 407 homosexual men
       with documented dates of seroconversion. Our data show that men who
       seroconverted early in the epidemic did not progress faster to Kaposi's
       sarcoma than men who seroconverted more recently. A lower incidence rate
       of Kaposi's sarcoma would be expected among the latter group if exposure
       to the hypothesized cofactor is decreasing over time. The percentage of
       Kaposi's sarcoma among incident AIDS cases decreased over the years
       following seroconversion, but not over calendar time. This study
       demonstrates that the decline in the proportion of Kaposi's sarcoma
       among AIDS cases should not be interpreted as a decline in the incidence
       of Kaposi's sarcoma and that there is no evidence that a hypothesized
       Kaposi's sarcoma cofactor is declining over calendar time.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/EPIDEMIOLOGY  Age of
       Onset  Cohort Studies  Homosexuality, Male  Human  HIV
       Seropositivity/*EPIDEMIOLOGY  Incidence  Male  Proportional Hazards
       Models  Prospective Studies  Sarcoma, Kaposi's/*EPIDEMIOLOGY/ETIOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).