Document 0718
 DOCN  M9610718
 TI    Self-treatment of female external genital warts with 0.5%
       podophyllotoxin cream (Condyline) vs weekly applications of 20%
       podophyllin solution.
 DT    9601
 AU    Hellberg D; Svarrer T; Nilsson S; Valentin J; Department of Obstetrics
       and Gynecology, Falun Hospital, Sweden.
 SO    Int J STD AIDS. 1995 Jul-Aug;6(4):257-61. Unique Identifier : AIDSLINE
       MED/96056095
 AB    Sixty women with genital warts were randomly allocated to treatment with
       either weekly application of 20% podophyllin solution or self-treatment
       with 0.5% podophyllotoxin cream twice daily for three days in weekly
       intervals. After a maximum of 4 treatment cycles a final assessment was
       carried out after 3 months. Primary clearance after termination of
       treatment was 82% for podophyllotoxin and 59% for podophyllin solution.
       After excluding relapses at the 3-month follow-up, final clearance for
       podophyllotoxin (71%) was significantly better (P < 0.05) than that for
       podophyllin solution (48%). The total frequency of warts eradicated was
       94% with podophyllotoxin and 74% with podophyllin solution (P < 0.001).
       Local adverse effects were generally mild or moderate. Podophyllotoxin
       cream provides a mode of easy application for women with external
       genital warts and had in this study a significantly better effect than
       podophyllin solution.
 DE    Administration, Cutaneous  Adolescence  Adult  Comparative Study
       Condylomata Acuminata/*DRUG THERAPY  Female  Follow-Up Studies  Genital
       Diseases, Female/*DRUG THERAPY  Human  Keratolytic Agents/*THERAPEUTIC
       USE  Middle Age  Ointments  Podophyllin/*THERAPEUTIC USE
       Podophyllotoxin/*THERAPEUTIC USE  Recurrence  Solutions  Support,
       Non-U.S. Gov't  CLINICAL TRIAL  JOURNAL ARTICLE  RANDOMIZED CONTROLLED
       TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).