Document 0729 DOCN M9610729 TI Stability of Th1 and Th2 populations. DT 9601 AU Perez VL; Lederer JA; Lichtman AH; Abbas AK; Department of Pathology, Brigham & Women's Hospital, Boston, MA; 02115, USA. SO Int Immunol. 1995 May;7(5):869-75. Unique Identifier : AIDSLINE MED/96053549 AB Using an in vitro model for the development of IFN-gamma-producing (Th1) and IL-4-producing (Th2) cells from CD4+ T lymphocytes expressing a transgenic TCR, we show that IL-12 and IL-4 are the most potent stimuli for the differentiation of naive T cells to effector populations. When combinations of cytokines are present during T cell priming, the effect of IL-4 is dominant. Furthermore, differentiated Th1 cells can be converted into IL-4 producers by exposure to IL-4, but the Th2 phenotype is not reversible. The stability of Th2 populations may limit the ability to regulate Th2-dominant responses in pathologic situations. DE Animal Cell Differentiation/DRUG EFFECTS/*IMMUNOLOGY Cells, Cultured CD4-Positive T-Lymphocytes/CYTOLOGY/IMMUNOLOGY Interleukin-12/PHARMACOLOGY Interleukin-4/PHARMACOLOGY Lymphocyte Transformation/DRUG EFFECTS/*PHYSIOLOGY Mice Mice, Transgenic Receptors, Antigen, T-Cell/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Th1 Cells/CYTOLOGY/*IMMUNOLOGY Th2 Cells/CYTOLOGY/*IMMUNOLOGY JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).