Document 0790
 DOCN  M9610790
 TI    Recurrent transient neurological deficits in advanced HIV infection.
 DT    9601
 AU    Baily GG; Mandal BK; Department of Infectious Diseases and Tropical
       Medicine, North; Manchester General Hospital, UK.
 SO    AIDS. 1995 Jul;9(7):709-12. Unique Identifier : AIDSLINE MED/96035233
 AB    OBJECTIVES: To report the occurrence of a syndrome of recurrent
       neurological deficits in advanced HIV disease and to discuss its
       management and prognosis. DESIGN: Retrospective case study. SETTING: A
       regional treatment centre for HIV-infected individuals in northwest
       England. MAIN OUTCOME MEASURES: Transient neurological deficit was
       defined as a focal neurological deficit of rapid onset which resolved
       completely within 24 h. Frequency, character and duration of episodes
       were recorded. Prior illnesses, CD4 count, changes in drug therapy and
       brain imaging investigations were also documented. RESULTS: Seven cases
       with recurrent transient neurological deficits were identified among 748
       patients over a 10-year period. Six had a CD4 cell count < 50 x 10(6)/l.
       The episodes lasted between 1 and 12 h and resolved completely without
       lasting sequelae. Dysphasia and hemiparesis were the most common
       presentations. Recurrent episodes for each patient tended to follow a
       similar pattern. None had computed tomographic evidence of cerebral
       infarction or clinical evidence of completed stroke. Prognosis was
       varied and not evidently altered by the episodes of neurological
       deficit. Three patients may have benefited from treatment with migraine
       prophylactics. CONCLUSION: A syndrome of recurrent transient
       neurological deficits may occur in advanced HIV disease. We believe that
       in some cases this may be due to local cerebral vasospasm, comparable to
       a classic migraine aura.
 DE    Adult  Case Report  Human  HIV Infections/*COMPLICATIONS/PATHOLOGY  Male
       Nervous System Diseases/*ETIOLOGY  Recurrence  JOURNAL ARTICLE

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