Document 0108
 DOCN  M9620108
 TI    [Incidence and differential diagnosis of cholestasis in AIDS--a
       retrospective analysis of 73 patients]
 DT    9602
 AU    Klinker H; Joeres R; Richter E; Medizinische Klinik, Universitat
       Wurzburg.
 SO    Z Gastroenterol. 1993 Feb;31 Suppl 2:126-8. Unique Identifier : AIDSLINE
       MED/96029875
 AB    A significant cholestasis constellation (alk. phosphatase and GGT each
       increased to twice as much as the norm) in 73 consecutive patients with
       AIDS was found in the course of the disease in 29 patients (= 39.7%). In
       most of the patients advanced immunodeficiency with an average of 2.5
       AIDS-defining diseases already existed. In the predominant number of
       cases it was intrahepatic cholestasis with only slight icterus.
       Therapeutic measures such as medicamentous treatment or high-caloric
       parenteral nutrition were causal in two thirds of the cases; in a
       quarter of the cases opportunistic infections, above all disseminating
       mycobacteriosis were found. One third of the patients had already
       existing liver diseases. Liver biopsy frequently proved diagnostic and
       should be performed more often in the case of unclear liver findings in
       AIDS patients.
 DE    Acquired Immunodeficiency Syndrome/*DIAGNOSIS/DRUG THERAPY/  PATHOLOGY
       Adult  Aged  Anti-Infective Agents/ADMINISTRATION & DOSAGE/ADVERSE
       EFFECTS  AIDS-Related Opportunistic Infections/DIAGNOSIS/DRUG THERAPY/
       PATHOLOGY  Cholestasis, Intrahepatic/CHEMICALLY
       INDUCED/*DIAGNOSIS/PATHOLOGY  Diagnosis, Differential  English Abstract
       Female  Human  Liver/PATHOLOGY  Liver Function Tests  Male  Middle Age
       Retrospective Studies  JOURNAL ARTICLE

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