Document 0166
 DOCN  M9620166
 TI    Cytotoxic T lymphocyte lysis inhibited by viable HIV mutants.
 DT    9602
 AU    Meier UC; Klenerman P; Griffin P; James W; Koppe B; Larder B; McMichael
       A; Phillips R; Nuffield Department of Clinical Medicine, John Radcliffe;
       Hospital, Headington, Oxford, UK.
 SO    Science. 1995 Nov 24;270(5240):1360-2. Unique Identifier : AIDSLINE
       MED/96085065
 AB    Immune evasion by the human immunodeficiency virus (HIV) is unexplained
       but may involve the mutation of viral antigens. When cytotoxic T
       lymphocytes engaged CD4-positive cells that were acutely infected with
       HIV bearing natural variant epitopes in reverse transcriptase,
       substantial inhibition of specific antiviral lysis was observed. Mutant
       viruses capable of these transactive effects could facilitate the
       persistence of a broad range of HIV variants in the face of an active
       and specific immune response.
 DE    Amino Acid Sequence  Antigenic Variation  Base Sequence  Cell Line
       *Cytotoxicity, Immunologic  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY/VIROLOGY  Epitopes/GENETICS  Human  HIV
       Antigens/GENETICS/*IMMUNOLOGY  HIV-1/ENZYMOLOGY/GENETICS/*IMMUNOLOGY
       HLA-B8 Antigen/IMMUNOLOGY  *Immune Tolerance  Molecular Sequence Data
       Receptors, Antigen, T-Cell/IMMUNOLOGY  RNA-Directed DNA
       Polymerase/GENETICS/*IMMUNOLOGY  Support, Non-U.S. Gov't  T-Lymphocytes,
       Cytotoxic/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).