Document 0215
 DOCN  M9620215
 TI    Toxoplasmosis and primary central nervous system lymphoma in HIV
       infection: diagnosis with MR spectroscopy.
 DT    9602
 AU    Chinn RJ; Wilkinson ID; Hall-Craggs MA; Paley MN; Miller RF; Kendall BE;
       Newman SP; Harrison MJ; Department of Radiology, Middlesex Hospital,
       University College; London Hospitals Trust, England.
 SO    Radiology. 1995 Dec;197(3):649-54. Unique Identifier : AIDSLINE
       MED/96072845
 AB    PURPOSE: To differentiate intracranial lymphoma from Toxoplasma gondii
       lesions in patients infected with the human immunodeficiency virus, by
       means of localized spin-echo proton magnetic resonance (MR)
       spectroscopy. MATERIALS AND METHODS: Twenty-seven lesions were studied
       (18 T gondii lesions, nine lymphoma lesions) at 1.5 T. Spectra were
       acquired at an echo time of 135 msec from voxels centered on the
       lesions. Both visual analysis and spectral fitting were used to obtain
       metabolite ratios for choline (Cho), creatine (Cr), N-acetyl (NA),
       lactate, and lipids. RESULTS: Three spectral categories were seen. One
       had large lipid peaks with suppression of other metabolites. Another had
       an elevated Cho/Cr ratio with relatively diminished NA. The third had
       features of the other two. Examples of each spectrum type were acquired
       from both T gondii and lymphoma lesions. Neither method of analysis
       allowed differentiation between lesion types. MR spectroscopy showed an
       overlap of spectra. CONCLUSION: The authors conclude that toxoplasmosis
       and lymphoma cannot be differentiated with spin-echo proton MR
       spectroscopy at 135 msec.
 DE    Adult  Aspartic Acid/ANALOGS & DERIVATIVES/METABOLISM  AIDS-Related
       Opportunistic Infections/*DIAGNOSIS/METABOLISM  Brain
       Neoplasms/*DIAGNOSIS/METABOLISM  Choline/METABOLISM  Creatine/METABOLISM
       Diagnosis, Differential  Female  Human  Lactates/METABOLISM
       Lipids/METABOLISM  Lymphoma, AIDS-Related/*DIAGNOSIS/METABOLISM
       Magnetic Resonance Imaging  Male  Middle Age  Nuclear Magnetic
       Resonance/*DIAGNOSTIC USE  Protons  Signal Processing, Computer-Assisted
       Support, Non-U.S. Gov't  Toxoplasmosis, Cerebral/*DIAGNOSIS/METABOLISM
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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