Document 0216
 DOCN  M9620216
 TI    Brain lesions in patients with AIDS: H-1 MR spectroscopy.
 DT    9602
 AU    Chang L; Miller BL; McBride D; Cornford M; Oropilla G; Buchthal S;
       Chiang F; Aronow H; Ernst T; Department of Neurology, Harbor-University
       of California Los; Angeles Medical Center, University of California Los
       Angeles; School of Medicine, Torrance 90509, USA.
 SO    Radiology. 1995 Nov;197(2):525-31. Unique Identifier : AIDSLINE
       MED/96027971
 AB    PURPOSE: To evaluate the role of proton (hydrogen-1) magnetic resonance
       (MR) spectroscopy in the differential diagnosis of focal brain lesions
       in patients with acquired immunodeficiency syndrome (AIDS). MATERIALS
       AND METHODS: Twenty-six men with 35 AIDS-related brain lesions underwent
       MR imaging and localized H-1 MR spectroscopy. Lesions consisted of 11
       toxoplasmic abscesses, 12 progressive multifocal leukoencephalopathic
       lesions, eight lymphomas, and four cryptococcomas. Metabolite peak areas
       in the lesions were compared with those in the contralateral hemisphere
       in each patient. RESULTS: H-1 MR spectroscopic findings showed
       significantly different biochemical profiles for each diagnostic group
       (P = .0001) with regard to N-acetyl compounds, total creatine pool,
       choline-containing compounds, myoinositol, and lactate. H-1 MR
       spectroscopy alone helped correctly diagnose 94% (84% with jackknifed
       classification) of the brain lesions, without overlap between
       toxoplasmosis and lymphoma. CONCLUSION: H-1 MR spectroscopy is a
       sensitive and potentially specific noninvasive adjunctive method for
       differential diagnosis of focal brain lesions in AIDS.
 DE    Abscess/DIAGNOSIS/METABOLISM/PARASITOLOGY  Adult  Aspartic Acid/ANALOGS
       & DERIVATIVES/METABOLISM  AIDS Dementia
       Complex/*DIAGNOSIS/METABOLISM/MICROBIOLOGY/  PARASITOLOGY  Brain
       Diseases/*DIAGNOSIS/METABOLISM/MICROBIOLOGY  Brain
       Neoplasms/DIAGNOSIS/METABOLISM  Choline/METABOLISM  Comparative Study
       Creatine/METABOLISM  Cryptococcosis/DIAGNOSIS/METABOLISM  Diagnosis,
       Differential  Human  Hydrogen  Inositol/METABOLISM  Lactates/METABOLISM
       Leukoencephalopathy, Progressive Multifocal/DIAGNOSIS/METABOLISM
       Lymphoma, AIDS-Related/DIAGNOSIS/METABOLISM  Magnetic Resonance Imaging
       Male  Middle Age  Nuclear Magnetic Resonance/*DIAGNOSTIC USE
       Sensitivity and Specificity  Support, U.S. Gov't, P.H.S.  Toxoplasmosis,
       Cerebral/DIAGNOSIS/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).