Document 0232
 DOCN  M9620232
 TI    Passive immunotherapy for retroviral disease: influence of major
       histocompatibility complex type and T-cell responsiveness.
 DT    9602
 AU    Hasenkrug KJ; Brooks DM; Chesebro B; Laboratory of Persistent Viral
       Diseases, Rocky Mountain; Laboratories, National Institute of Allergy
       and Infectious; Diseases, National Institutes of Helath, Hamilton, MT
       59840, USA.
 SO    Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10492-5. Unique Identifier :
       AIDSLINE MED/96068641
 AB    Administration of virus-specific antibodies is known to be an effective
       early treatment for some viral infections. Such immunotherapy probably
       acts by antibody-mediated neutralization of viral infectivity and is
       often thought to function independently of T-cell-mediated immune
       responses. In the present experiments, we studied passive antibody
       therapy using Friend murine leukemia virus complex as a model for an
       immunosuppressive retroviral disease in adult mice. The results showed
       that antibody therapy could induce recovery from a well-established
       retroviral infection. However, the success of therapy was dependent on
       the presence of both CD4+ and CD8+ T lymphocytes. Thus, cell-mediated
       responses were required for recovery from infection even in the presence
       of therapeutic levels of antibody. The major histocompatibility type of
       the mice was also an important factor determining the relative success
       of antibody therapy in this system, but it was less critical for
       low-dose than for high-dose infections. Our results imply that limited
       T-cell responsiveness as dictated by major histocompatibility genes
       and/or stage of disease may have contributed to previous immunotherapy
       failures in AIDS patients. Possible strategies to improve the efficacy
       of future therapies are discussed.
 DE    Acquired Immunodeficiency Syndrome/THERAPY  Animal  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female
       *Friend Virus  *Immunotherapy, Adoptive  Lymphocyte Depletion  *Major
       Histocompatibility Complex  Mice  Retroviridae Infections/*THERAPY
       Survival Analysis  T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

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