Document 0263
 DOCN  M9620263
 TI    Soluble E-selectin in the serum and cerebrospinal fluid of patients with
       multiple sclerosis and human T-lymphotropic virus type 1-associated
       myelopathy.
 DT    9602
 AU    Tsukada N; Miyagi K; Matsuda M; Yanagisawa N; Health Medical Center,
       Shinshu University, Matsumoto, Japan.
 SO    Neurology. 1995 Oct;45(10):1914-8. Unique Identifier : AIDSLINE
       MED/96022174
 AB    To evaluate the activation of endothelial cells of the brain and the
       spinal cord, we investigated the presence of soluble endothelial
       leukocyte adhesion molecule-1 (sE-selectin) in the serum and
       cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and
       those with human T-lymphotropic virus type 1-associated myelopathy
       (HAM). There were significantly higher levels of sE-selectin found in
       the serum of patients with relapsing-remitting MS during an exacerbation
       (p < 0.001) and those with chronic progressive MS (p < 0.01) compared
       with controls. Serum levels of sE-selectin in patients with HAM did not
       differ significantly from serum levels in controls or non-HAM carriers.
       We also found sE-selectin in the CSF of eight patients during an
       exacerbation of relapsing-remitting MS. These results suggest that an
       active immune reaction involving E-selectin production that is
       indicative of endothelial cell damage occurs in the CNS of patients
       during an exacerbation of relapsing-remitting MS. Thus, sE-selectin may
       be useful in monitoring disease activity in patients with
       relapsing-remitting MS.
 DE    Adult  E-Selectin/*BLOOD/*CEREBROSPINAL FLUID  Enzyme-Linked
       Immunosorbent Assay  Female  Human  HTLV-I
       Infections/*BLOOD/*CEREBROSPINAL FLUID  Male  Middle Age  Multiple
       Sclerosis/*BLOOD/*CEREBROSPINAL FLUID  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

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