Document 0303
 DOCN  M9620303
 TI    Immune response to changes in training intensity and volume in runners.
 DT    9602
 AU    Kajiura JS; MacDougall JD; Ernst PB; Younglai EV; Department of
       Kinesiology, McMaster University, Hamilton,; Ontario, Canada.
 SO    Med Sci Sports Exerc. 1995 Aug;27(8):1111-7. Unique Identifier :
       AIDSLINE MED/96021390
 AB    We examined the acute and chronic effects of changes in training volume
       and intensity on the blood lymphocyte percentages and immunoglobulin
       levels in runners. Twelve runners participated in four 10-d phases of
       low volume/low intensity (LV/LI), high volume/low intensity (HV/LI), or
       high volume/high intensity (HV/HI) running. Subjects were assigned to
       one of two different training group orders: 1) LV/LI, HV/LI, LV/LI,
       HV/HI; or 2) LV/LI, HV/HI, LV/LI, HV/LI. Venous blood was drawn at rest
       on days 1, 4, and 7; and 5 min post-exercise on days 1 and 7 of each
       10-d phase. Lymphocyte subsets were determined by flow cytometry for
       CD3+, CD4+, CD8+, and HLA-DR+. IgG, and IgM levels were obtained by
       ELISA analysis. Immunoglobulin, CD8+ and HLA-DR+ levels, and
       pre-exercise plasma cortisol concentrations were not significantly
       affected by alterations in volume or intensity. A transient decrease (P
       < 0.05) was observed in CD4+ and the CD4/CD8 ratio 5 min post-exercise
       during the HV/LI and HV/HI phases. Results indicate that the
       exercise-induced lymphocyte subset reduction is transient and suggest
       that it is more dependent upon training intensity than volume, and the
       training order of exposure to the high-intensity stimulus may determine
       the magnitude of subsequent responses.
 DE    Adolescence  Adult  CD4 Lymphocyte Count  CD4-CD8 Ratio  CD4-Positive
       T-Lymphocytes/CYTOLOGY  CD8-Positive T-Lymphocytes/CYTOLOGY  Flow
       Cytometry  Human  Hydrocortisone/BLOOD  HLA-DR Antigens/ANALYSIS
       IgA/BLOOD  IgG/BLOOD  IgM/BLOOD  Immunoglobulins/*BLOOD  Lymphocyte
       Count  Male  Physical Education and Training  Running/*PHYSIOLOGY
       Support, Non-U.S. Gov't  T-Lymphocyte Subsets/CYTOLOGY
       T-Lymphocytes/*CYTOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).