Document 0304
 DOCN  M9620304
 TI    In vivo effects of superantigens.
 DT    9602
 AU    Blackman MA; Woodland DL; Department of Immunology, St. Jude Children's
       Research Hospital,; Memphis, TN 38105, USA.
 SO    Life Sci. 1995 Sep 29;57(19):1717-35. Unique Identifier : AIDSLINE
       MED/96068852
 AB    Superantigens are potent immunostimulatory molecules that activate both
       T cells and antigen presenting cells. The consequences of superantigen
       exposure range from induction of T cell proliferation, massive cytokine
       release and systemic shock to immunosuppression and tolerance.
       Superantigens have been directly implicated in a number of human
       conditions including food poisoning and toxic shock. In addition, there
       is evidence to suggest that superantigens are involved in the initiation
       of autoimmunity, and the immune dysfunction associated with HIV
       infection. Because of their possible role in human disease, and their
       potential use in immune therapy, it is important that we more completely
       understand the in vivo effects of superantigens.
 DE    Animal  Human  Immune Tolerance
       Superantigens/*IMMUNOLOGY/*PHARMACOLOGY/TOXICITY  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).