Document 0306
 DOCN  M9620306
 TI    Mucociliary clearance abnormalities in the HIV-infected patient: a
       precursor to acute sinusitis.
 DT    9602
 AU    Milgrim LM; Rubin JS; Small CB; Department of Otolaryngology, Mount
       Sinai Medical Center, New; York, N.Y., USA.
 SO    Laryngoscope. 1995 Nov;105(11):1202-8. Unique Identifier : AIDSLINE
       MED/96069679
 AB    An increasing number of patients with human immunodeficiency virus (HIV)
       suffer from acute infectious sinusitis, and many suffer recurrent
       episodes at a higher rate than their non-HIV counterparts. This study
       investigates a mechanism underlying the increased incidence of
       sinusitis, that of prolonged mucociliary transport time (MTT). Nasal
       mucociliary clearance was examined in 30 HIV-infected patients and 30
       matched, non-HIV controls using a nasal saccharin transport test. MTTs
       for the study group and the controls were 11.9 +/- 5.9 minutes and 7.4
       +/- 3.7 minutes, respectively. This difference attained statistical
       significance (P < .05). Study group patients with a history of sinusitis
       had a mean MTT of 13.7 +/- 6.8 minutes. Those with complaints of new
       onset nasal obstruction since HIV conversion had a mean MTT of 13.5 +/-
       6.8 minutes. Statistical significance (P < .05) was found comparing
       these times to controls, as well as to study patients without these
       symptoms. These data support an inherent delay of mucociliary clearance
       in HIV-infected patients which is chronic, possibly irreversible, and,
       in association with nasal obstruction, represents a major mechanism of
       both the high acute and recurrent sinusitis rate in this population. The
       cause of the mucociliary delay is still unclear and needs to be further
       investigated.
 DE    Acute Disease  Adult  Cross-Sectional Studies  Female  Human  HIV
       Infections/COMPLICATIONS/*PHYSIOPATHOLOGY  Male  Middle Age
       *Mucociliary Clearance  Nasal Obstruction/ETIOLOGY  Pilot Projects
       Sinusitis/*ETIOLOGY  Support, U.S. Gov't, P.H.S.  Time Factors  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).