Document 0488
 DOCN  M9620488
 TI    High prevalence of human T cell lymphotropic virus type II infection in
       patients affected by human immunodeficiency virus type 1--associated
       predominantly sensory polyneuropathy.
 DT    9602
 AU    Zehender G; De Maddalena C; Osio M; Cavalli B; Parravicini C; Moroni M;
       Galli M; Clinica delle Malattie Infettive, University of Milan, Italy.
 SO    J Infect Dis. 1995 Dec;172(6):1595-8. Unique Identifier : AIDSLINE
       MED/96083509
 AB    The etiopathogenesis of peripheral neuropathy (PN) that frequently
       affects human immunodeficiency virus (HIV) type 1-positive patients
       remains undefined. Forty-seven HIV-1-positive patients with PN (8 with
       inflammatory demyelinating polyneuropathy and 39 with predominantly
       sensory polyneuropathy [PSP]) and 266 controls with symptomatic HIV-1
       infection without PN were screened for antibodies to human T cell
       lymphotropic virus (HTLV) types I and II. The prevalence of antibodies
       to HTLV-II was significantly higher in patients with PSP than in
       controls (30.8% vs. 8.3%; P < .001). All seropositive patients with PN
       had HTLV-II DNA in their peripheral blood mononuclear cells by
       polymerase chain reaction (PCR) analysis. PCR analysis of tissues from 1
       patient with PSP who died during the study showed HTLV-II proviral
       sequences in the femoral nerve and basal nuclei. These results support
       the hypothesis that HTLV-II represents an etiologic factor in the
       pathogenesis of a considerable proportion of PSP in patients infected
       with HIV-1.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  DNA,
       Viral/ANALYSIS  Female  Human  *HIV-1  HTLV-II Antibodies/BLOOD  HTLV-II
       Infections/*COMPLICATIONS/EPIDEMIOLOGY  Male  Peripheral Nervous System
       Diseases/*ETIOLOGY  Polymerase Chain Reaction  Prevalence  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).