Document 0584
 DOCN  M9620584
 TI    Effect of vitamin and trace element supplementation on immune indices in
       healthy elderly.
 DT    9602
 AU    Pike J; Chandra RK; Department of Pediatrics, Memorial University of
       Newfoundland,; St. John's, Canada.
 SO    Int J Vitam Nutr Res. 1995;65(2):117-21. Unique Identifier : AIDSLINE
       MED/96089946
 AB    Aging is associated with a progressive decline in the immune system and
       a greater susceptibility to infection. This double-blind,
       placebo-controlled study, examined the effect of a vitamin and trace
       element supplement on immune responses of healthy, noninstitutionalized
       elderly subjects. Forty-seven subjects aged 61-79 years were randomly
       assigned to receive placebo or micronutrient supplementation for one
       year. Thirty-five individuals completed the one-year study. Immune
       function was assessed before and after the period of supplementation.
       Cell-mediated immune function assessed by the number of T cells and
       subsets remained constant in the supplemented group and there was a
       significant increase in CD57 natural killer cells. In contrast, a
       significant decrease in T cells, CD4 cells, and CD4: CD8 ratio was noted
       in the placebo group. Supplementation with micronutrients can play a
       crucial role in the maintenance of normal immune function in the
       elderly.
 DE    Aged  Aging/*IMMUNOLOGY  Antigens, CD3/ANALYSIS  Antigens, CD4/ANALYSIS
       Antigens, CD57/ANALYSIS  Antigens, CD8/ANALYSIS  CD4-CD8 Ratio
       Double-Blind Method  Female  Food, Fortified  Human  Immune System/*DRUG
       EFFECTS/PHYSIOLOGY  Killer Cells, Natural/IMMUNOLOGY/PHYSIOLOGY  Male
       Middle Age  Support, Non-U.S. Gov't  T-Lymphocytes/IMMUNOLOGY/PHYSIOLOGY
       Trace Elements/ADMINISTRATION & DOSAGE/*PHARMACOLOGY
       Vitamins/ADMINISTRATION & DOSAGE/*PHARMACOLOGY  CLINICAL TRIAL  JOURNAL
       ARTICLE  RANDOMIZED CONTROLLED TRIAL

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