Document 0595
 DOCN  M9620595
 TI    The effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte
       subsets during a contact hypersensitivity response in the NOD mouse.
 DT    9602
 AU    Gugasyan R; Losinno C; Mandel T; Walter and Eliza Hall Institute of
       Medical Research, Parkville,; Victoria, Australia.
 SO    Immunol Lett. 1995 Jun;46(3):221-7. Unique Identifier : AIDSLINE
       MED/96089928
 AB    The compound 2-acetyl-4-tetrahydroxybutylimidazole (THI) is known to
       suppress a contact hypersensitivity (CH) response. The effect of THI on
       lymphocyte subsets during treatment and in a CH response has not been
       shown in mice. To further define the immunosuppressive potential of THI,
       a time-course study during the CH response to oxazolone (OX) was
       performed. While THI can prevent the induction of CH, if treatment is
       started before sensitization, it has a low therapeutic capability since
       it could not significantly inhibit the response when continuous oral
       treatment was commenced during the course of CH. We report that during
       this response continuous oral treatment of non-obese diabetic (NOD) mice
       with THI reduced the number of CD4+ and CD8+ T cells in the peripheral
       blood. In the draining lymph nodes THI treatment had no effect on
       lymphocyte subsets prior to contact sensitization, but subsequent
       sensitization and elicitation with OX could not stimulate a significant
       increase in the number of CD4+ T cells in the treated mice, whereas
       untreated control mice showed elevated numbers of these lymphocytes.
       These findings suggest that THI can inhibit an CH response by preventing
       the recruitment of CD4+ T cells in the draining lymph nodes through an
       unknown mechanism.
 DE    Animal  Cell Count  CD4-Positive T-Lymphocytes/DRUG EFFECTS
       CD8-Positive T-Lymphocytes/DRUG EFFECTS  Dermatitis, Contact/BLOOD/DRUG
       THERAPY/*IMMUNOLOGY  Female  Imidazoles/*PHARMACOLOGY/THERAPEUTIC USE
       Immunosuppressive Agents/*PHARMACOLOGY/THERAPEUTIC USE  Lymph Nodes/DRUG
       EFFECTS  Lymphopenia/CHEMICALLY INDUCED  Mice  Mice, Inbred NOD
       Support, Non-U.S. Gov't  T-Lymphocyte Subsets/*DRUG EFFECTS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).