Document 0601
 DOCN  M9620601
 TI    Increased level of activated gamma delta lymphocytes correlates with
       disease severity in HIV infection.
 DT    9602
 AU    Norazmi MN; Arifin H; Jamaruddin MA; Department of Immunology, School of
       Medical Sciences, Universiti; Sains Malaysia, Kelantan.
 SO    Immunol Cell Biol. 1995 Jun;73(3):245-8. Unique Identifier : AIDSLINE
       MED/96082312
 AB    The lymphocyte subset expressing the gamma delta T cell receptor is
       increased in several infectious diseases including HIV infection. In
       this study the expression on gamma delta lymphocytes of the T cell
       activation markers CD25, HLA-DR and CD38, as well as the two isoforms of
       CD45, namely CD45RA and CD45RO, was determined in the peripheral blood
       of 56 HIV-infected intravenous drug users and 34 HIV-seronegative blood
       donors by two-colour flow cytometry. The percentage of gamma delta
       lymphocytes expressing HLA-DR and CD38 was higher than those in
       HIV-seronegative controls (P < 0.001 and P < 0.0001, respectively).
       Furthermore the HLA-DR+gamma delta+ lymphocytes correlated inversely
       with CD4+ T lymphocyte absolute count (P < 0.02 for both). The levels of
       gamma delta lymphocytes expressing CD25, CD45RA and CD45RO were similar
       to those in HIV-seronegative controls. Activated gamma delta lymphocytes
       may play a role in the HIV disease process and could provide a useful
       marker for disease progression.
 DE    Adolescence  Adult  Antigens, CD45/ANALYSIS  Antigens,
       Differentiation/ANALYSIS  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/*METABOLISM  Female  Human  HIV Infections/*IMMUNOLOGY
       HLA-DR Antigens/ANALYSIS  Lymphocyte Transformation/*IMMUNOLOGY  Male
       Nucleosidases/ANALYSIS  Receptors, Antigen, T-Cell,
       gamma-delta/*ANALYSIS  Receptors, Interleukin-2/ANALYSIS  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).