Document 0636
 DOCN  M9620636
 TI    HIV-related non-Hodgkin's lymphoma among European AIDS patients. AIDS in
       Europe Study Group. AIDS in Europe Study Group.
 DT    9602
 AU    Pedersen C; Barton SE; Chiesi A; Skinhoj P; Katlama C; Johnson A; van
       Lunzen J; Hirschel B; Maayan S; Lundgren JD; Department of Infectious
       Disease, State University Hospital,; Copenhagen, Denmark.
 SO    Eur J Haematol. 1995 Oct;55(4):245-50. Unique Identifier : AIDSLINE
       MED/96013862
 AB    The epidemiology of HIV associated non-Hodgkin's lymphoma (NHL) was
       investigated in 6550 European patients with AIDS. NHL was diagnosed in
       3.5% of all patients at the time of the AIDS diagnosis. Although the
       probability of being diagnosed with NHL at AIDS diagnosis was
       significantly higher among intravenous drug users than among homosexual
       men, and was associated with increasing age, the observed incidences of
       NHL were more strikingly similar than any differences. The rate of
       developing NHL after a previous AIDS diagnosis was 2.4 per 100 patient
       years of follow-up, and remained constant during a 5-year follow-up
       period. While primary brain lymphomas comprised only 9% of NHL diagnosed
       at the time of AIDS, they comprised 38% of NHL diagnosed after AIDS (p <
       0.001). The prognosis for patients with NHL at AIDS diagnosis was poor
       with a median survival of 5 months. A diagnosis of primary brain
       lymphoma was uniformly associated with a poor outcome. It is concluded
       that the probability of developing NHL in late stage HIV infection is
       lower than previously anticipated from the results of small studies on
       patients receiving long-term anti-retroviral therapy.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  Adult  Age Factors
       Comparative Study  Europe/EPIDEMIOLOGY  Female  Homosexuality, Male
       Human  *HIV  HIV Infections/*EPIDEMIOLOGY  Incidence  Lymphoma,
       AIDS-Related/*EPIDEMIOLOGY/MORTALITY  Male  Probability  Sex
       Characteristics  Substance Abuse, Intravenous  Survival Rate  JOURNAL
       ARTICLE  MULTICENTER STUDY

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