Document 0659
 DOCN  M9620659
 TI    Role of antigenemia assay in the early diagnosis and prediction of human
       cytomegalovirus organ involvement in AIDS patients.
 DT    9602
 AU    Francisci D; Tosti A; Preziosi R; Baldelli F; Stagni G; Pauluzzi S;
       Institute of Infectious Diseases, University of Perugia,; Policlinico
       Monteluce, Italy.
 SO    Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):498-503. Unique
       Identifier : AIDSLINE MED/96082793
 AB    The role of an antigenemia assay in the diagnosis and prediction of
       human cytomegalovirus (HCMV) disease in AIDS patients was evaluated. The
       clinical history of 62 patients with advanced HIV infection from whom a
       total of 248 blood samples were drawn and tested by the HCMV antigenemia
       assay was examined retrospectively. Between December 1992 and January
       1994, 28 episodes of HCMV disease with organ involvement were recorded;
       the antigenemia assay was positive in 23 of them (82.1%). In particular,
       this test was positive in 11 of 12 (91.6%) first episodes and in 3 of 3
       (100%) recurrent episodes occurring in patients not receiving
       maintenance therapy. The same test was positive in 9 of 13 (69.2%)
       recurrent episodes occurring in patients receiving maintenance therapy.
       The first occurrence of HCMV disease was always preceded by a positive
       antigenemia assay 2 and 4 months before diagnosis (in all 7 patients of
       the 7 for whom a blood sample was available before HCMV disease). A
       positive antigenemia test result was not always followed by organ
       involvement, but a high positive cell count (> 100/200,000
       polymorphonuclear leukocytes) strongly correlated with the appearance of
       HCMV disease in the following 1 to 3 months (100% of cases). The
       antigenemia assay is a useful and reliable indirect method for the
       diagnosis and prediction of HCMV end-organ disease in severely and
       persistently immunocompromised AIDS patients.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*COMPLICATIONS  Adolescence
       Adult  Aged  Antigens, Viral/*BLOOD  AIDS-Related Opportunistic
       Infections/BLOOD/COMPLICATIONS/  *DIAGNOSIS  Child  Child, Preschool
       Cytomegalovirus/ISOLATION & PURIF  Cytomegalovirus
       Infections/BLOOD/COMPLICATIONS/*DIAGNOSIS  Female  Fluorescent Antibody
       Technique, Indirect  Human  Linear Models  Male  Middle Age  Predictive
       Value of Tests  Retrospective Studies  Serodiagnosis  JOURNAL ARTICLE

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