Document 0685
 DOCN  M9620685
 TI    [Use of parenteral nutritional support in patients with gastric cancer:
       the relationship of protein turn over, immunocompetence and tumor cell
       kinetics]
 DT    9602
 AU    Cao W; Lin Y; Yin H; Ruijin Hospital, Shanghai Second Medical
       University.
 SO    Chung Hua Wai Ko Tsa Chih. 1995 May;33(5):265-8. Unique Identifier :
       AIDSLINE MED/96041504
 AB    In order to elucidate the effect of preoperative parenteral nutritional
       support (PNS) on protein metabolism, host immunocompetence and tumor
       cell kinetics, two prospective trials were made in patients with gastric
       cancer. All the patients were given PNS for 7 days in addition to oral
       intake. The positive nitrogen balance and increase of protein anabolic
       rate was greater in PNS groups than in control group. There was a
       moderate increase in NKC after PNS. The rise in CD4+ was significant (P
       < 0.05). The percentage of G0/G1 cells fell after PNS (P < 0.01), while
       that of the whole proliferative phase (S + G2 + M) rose (P < 0.05).
       These changes were not noted in normal gastric mucosa. In conclusion,
       despite of stimulating tumor cell proliferation, PNS helps to promote
       whole body protein synthesis and to amelio-rate the immunocompetence of
       advanced gastric cancer patients before operation.
 DE    Adult  Aged  Cell Cycle  CD4-CD8 Ratio  English Abstract  Female  Human
       *Immunocompetence  Killer Cells, Natural/IMMUNOLOGY  Male  Middle Age
       *Parenteral Nutrition  Prealbumin/METABOLISM  Preoperative Care
       Prospective Studies  Stomach Neoplasms/BLOOD/PATHOLOGY/*THERAPY
       Transferrin/METABOLISM  CLINICAL TRIAL  JOURNAL ARTICLE  RANDOMIZED
       CONTROLLED TRIAL

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