Document 0731
 DOCN  M9620731
 TI    Effect of HIV vertical transmission on the ontogeny of T cell antigens
       involved in the regulation of humoral immune response.
 DT    9602
 AU    Brugnoni D; Soresina A; Airo P; Ugazio AG; Notarangelo LD; Cattaneo R;
       Duse M; Clinical Immunology Service, Spedali Civili, Brescia, Italy.
 SO    Clin Exp Immunol. 1995 Nov;102(2):238-42. Unique Identifier : AIDSLINE
       MED/96069869
 AB    HIV infection causes progressive impairment of humoral immunity,
       including defective specific antibody production. To evaluate whether
       vertical HIV infection interferes with the expression on CD4+
       lymphocytes of developmentally regulated molecules, that play a crucial
       role in the generation of immunological memory (CD45 isoforms) and in
       attainment of antibody responses (CD40L), 22 HIV-infected children and
       36 seroreverted children born to HIV+ mothers were studied. The
       percentage of CD40L+ PBMC after activation in vitro with phorbol
       myristate acetate (PMA) plus ionomycin was lower in HIV-infected
       children than in controls (P < 0.004). This correlated with the
       depletion of CD4+ lymphocytes (r = 0.75; P < 0.001). CD40L expression
       rose progressively with age (r = 0.36; P = 0.03) in seroreverted
       children, but not in HIV-infected children, suggesting that while in
       normal children in vivo antigen stimulation results in progressive
       attainment of CD40L expression (and thus to effective T-B cell
       cooperation), this process is largely defective in HIV-infected
       children, contributing to the genesis of humoral immune deficiency. The
       proportion of CD4+ cells bearing the CD45RO isoform was increased among
       HIV-infected infants during the first years of life. However, the
       percentage of CD4+ CD45RO+ peripheral blood mononuclear cells (PBMC)
       progressively increased with age in controls (r = 0.69; P = 0.03), but
       not in HIV-infected children, showing that while vertical transmission
       of HIV does not prevent CD45RO expression early in life, it is
       associated with a disturbance of the physiological process of antigen
       priming, contributing to poor immunological memory to T cell-dependent
       antigens.
 DE    Age Factors  Antigens, CD45/*METABOLISM  Child  Child, Preschool
       CD4-Positive T-Lymphocytes/*IMMUNOLOGY  Disease Transmission, Vertical
       Female  Human  HIV/*IMMUNOLOGY  HIV Infections/*CONGENITAL/TRANSMISSION
       Infant  Male  Membrane Glycoproteins/*METABOLISM  Support, Non-U.S.
       Gov't  T-Lymphocyte Subsets/IMMUNOLOGY  JOURNAL ARTICLE

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