Document 0768
 DOCN  M9620768
 TI    Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The
       Multicenter AIDS Cohort Study [see comments]
 DT    9602
 AU    Margolick JB; Munoz A; Donnenberg AD; Park LP; Galai N; Giorgi JV;
       O'Gorman MR; Ferbas J; Department of Molecular Biology and Immunology,
       Johns Hopkins; University School of Hygiene and Public Health,
       Baltimore,; Maryland 21205-2179, USA.
 SO    Nat Med. 1995 Jul;1(7):674-80. Unique Identifier : AIDSLINE MED/96071530
 CM    Comment in: Nat Med 1995 Jul;1(7):621-2
 AB    We and others have postulated that a constant number of T lymphocytes is
       normally maintained without regard to CD4+ or CD8+ phenotype ('blind'
       T-cell homeostasis). Here we confirm essentially constant T-cell levels
       (despite marked decline in CD4+ T cells and increase in CD8+ T cells) in
       homosexual men with incident human immunodeficiency virus, type 1
       (HIV-1), infection who remained free of acquired immunodeficiency
       syndrome (AIDS) for up to eight years after seroconversion. In contrast,
       seroconverters who developed AIDS exhibited rapidly declining T cells
       (both CD4+ and CD8+) for approximately two years before AIDS,
       independent of the time between seroconversion and AIDS, suggesting that
       homeostasis failure is an important landmark in HIV disease progression.
       Given the high rate of T-cell turnover in HIV-1 infection, blind T-cell
       homeostasis may contribute to HIV pathogenesis through a CD8+ T
       lymphocytosis that interferes with regeneration of lost CD4+ T cells.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PHYSIOPATHOLOGY  Cohort
       Studies  CD4-CD8 Ratio  CD4-Positive T-Lymphocytes/*PATHOLOGY
       CD8-Positive T-Lymphocytes/*PATHOLOGY  Disease Progression
       *Hematopoiesis  Homeostasis  Homosexuality  Human  HIV
       Infections/IMMUNOLOGY/*PHYSIOPATHOLOGY  HIV Seropositivity/IMMUNOLOGY
       *HIV-1  *Lymphocyte Count  Lymphocytosis/ETIOLOGY  Male  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Time Factors  JOURNAL
       ARTICLE

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