Document 0781
 DOCN  M9620781
 TI    Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient
       leads to selection for mutant HIV variants and subsequent disease
       progression [see comments]
 DT    9602
 AU    Koenig S; Conley AJ; Brewah YA; Jones GM; Leath S; Boots LJ; Davey V;
       Pantaleo G; Demarest JF; Carter C; et al; MedImmune, Inc., Gaithersburg,
       Maryland 20878, USA.
 SO    Nat Med. 1995 Apr;1(4):330-6. Unique Identifier : AIDSLINE MED/96071442
 CM    Comment in: Nat Med 1995 Apr;1(4):304-5
 AB    An HIV-1-seropositive volunteer was infused with an expanded autologous
       cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 nef
       protein. This clone was adoptively transferred to determine whether
       supplementing CTL activity could reduce viral load or improve clinical
       course. Unexpectedly, infusion was followed by a decline in circulating
       CD4+ T cells and a rise in viral load. Some of the HIV isolates obtained
       from the plasma or CD4+ cells of the patient were lacking the nef
       epitope. These results suggest that active CTL selection of viral
       variants could contribute to the pathogenesis of AIDS and that clinical
       progression can occur despite high levels of circulating HIV-1-specific
       CTLs.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/PHYSIOPATHOLOGY/  *THERAPY
       Amino Acid Sequence  Base Sequence  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Disease
       Progression  DNA Primers/CHEMISTRY  DNA, Viral/ANALYSIS  Gene
       Amplification  Gene Products, nef/GENETICS/IMMUNOLOGY  Human  HIV
       Antibodies/ANALYSIS  HIV Core Protein p24/IMMUNOLOGY  HIV
       Seropositivity/IMMUNOLOGY/PHYSIOPATHOLOGY/THERAPY
       HIV-1/*GENETICS/*IMMUNOLOGY/PHYSIOLOGY  *Immunotherapy, Adoptive
       Molecular Sequence Data  Mutation  Nucleic Acid Hybridization
       T-Lymphocytes, Cytotoxic/*IMMUNOLOGY  Virus Replication  JOURNAL ARTICLE

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