Document 0811
 DOCN  M9620811
 TI    Testing HIV molecular biology in in silico physiologies.
 DT    9602
 AU    Sieburg HB; Baray C; Kunzelman KS; Department of Psychiatry, University
       of California, San Diego; 92093-0603, USA.
 SO    Ismb. 1993;1:354-61. Unique Identifier : AIDSLINE MED/96038985
 AB    The natural and medical sciences have strongly benefitted from
       technological advances that help to create and store more raw
       information than can be effectively processed. In particular, this rapid
       growth has created a strong need for a flexible and far-reaching
       approach to cross-database simulation. The paper uses a highly
       simplified example, called the 'TinyMouse' simulator, to explain the
       design and functioning of interactive cross-database simulators that can
       be applied to prototype experiments with animal models of human disease,
       such as the hu-SCID mouse model for the Acquired Immune Deficiency
       Syndrome (AIDS). Work in progress is discussed to extend 'TinyMouse'
       into 'CyberMouse', an informational organism that synthesizes factual
       databases of the murine neuroendocrine-immune system.
 DE    Animal  Computer Communication Networks  *Computer Simulation  Human
       HIV/GENETICS  *HIV Infections  *Immune System  Mice  Mice, SCID
       *Models, Biological  Models, Genetic  Software Design  Support, U.S.
       Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).