Document 0847
 DOCN  M9620847
 TI    The 90K tumor-associated antigen and clinical progression in human
       immunodeficiency virus infection.
 DT    9602
 AU    Iacobelli S; Ullrich A; Tinari N; Ortona L; Tamburrini E; D'Egidio M;
       Ghinelli F; Sighinolfi L; Piazza M; Chirianni A; et al; University G.
       D'Annunzio Medical School, Chieti, Italy.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):450-6.
       Unique Identifier : AIDSLINE MED/96074278
 AB    We investigated the possibility that a secreted glycoprotein of
       approximately 90,000 daltons, termed 90K and identified as a member of
       the protein superfamily characterized by the scavenger receptor
       cysteine-rich (SRCR) domain, might have value as a predictor of
       progression to acquired immunodeficiency syndrome (AIDS) in subjects
       infected with the human immunodeficiency virus (HIV). Among 488
       HIV-seropositive intravenous drug users with a median follow-up of 32.5
       months, high levels of serum 90K at baseline proved to be a significant
       predictor of faster progression to AIDS, either as a continuous variable
       (log 90K; p < 0.0001) or as a dichotomous variable with an optimized
       cutoff point of 30 U/ml (p < 0.00001). Analysis of 90K in relation to
       known prognostic factors found an association with CD4 count, beta
       2-microglobulin, and p24 antigen but none with neopterin. In
       multivariate analysis, the baseline 90K level was an independent
       predictor of AIDS. As compared with subjects with low levels of 90K, the
       relative risk of developing AIDS was 3.5 (95% CI 1.9-6.5) among those
       with high levels of 90K. The predictive value of 90K was maintained
       after stratification by baseline CD4 count: among subjects with > or =
       500 x 10(6)/L CD4 cells, the proportion in whom AIDS developed was 10.5%
       for those with 90K levels < or = 30 U/ml as compared with 20% for those
       with 90K above the cutoff point (p = 0.006). Serum 90K is an independent
       predictor of the risk for progression to AIDS in HIV-infected subjects,
       including those whose CD4 counts have not fallen.
 DE    beta 2-Microglobulin/ANALYSIS  Acquired Immunodeficiency
       Syndrome/DIAGNOSIS/PHYSIOPATHOLOGY  Adolescence  Adult  Antigens,
       Neoplasm/*BLOOD  Biological Markers  Biopterin/ANALOGS &
       DERIVATIVES/BLOOD  CD4 Lymphocyte Count  Disease Progression  Female
       Human  HIV Core Protein p24/BLOOD  HIV
       Seropositivity/*BLOOD/PHYSIOPATHOLOGY  Immunoradiometric Assay  Male
       Middle Age  Multivariate Analysis  Prognosis  Prospective Studies
       Substance Abuse, Intravenous/*BLOOD/PHYSIOPATHOLOGY  JOURNAL ARTICLE

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